Translation of the scientific study: “ Molecular and biochemical mechanism of cannabldiol in the management of inflammatory and oxidative processes associated with endometriosis ”
Okten SB, Cetin C, Tok OE, Guler EM, Taha SH, Ozcan P, Ficicioglu C.
Reprod Biomed Online. 2023 May;46(5):865-875. doi: 10.1016/j.rbmo.2023.01.018. Epub 2023 Feb 2.
PMID: 36997400"
Endometriosis is usually associated with inflammation and chronic pelvic pain.
This article focuses on the anti-inflammatory, antioxidant and analgesic effects of cannabldiol (C8D) and its potential role in endometriosis.
Administration of C8D markedly reduced the diameter, volume and surface area of the lesions.
In particular, C8D was able to modify the morphology of the lesions, reducing epithelial glands and stroma. C8D showed anti-oxidant effects reducing lipid peroxidation, expression of Nox-1 and Nox-4 enzymes. C8D restored the oxidative balance of endogenous cellular defense, as shown by SOD activity and GSH levels in lesions. C8D also showed significant antifibrotic effects, as shown by Masson's trichrome staining and reduced expression of MMP-9, iNOS, and TGF-β. C8D was able to reduce inflammation both in the sampled lesions, as shown by the increase in Ikb-α and the reduction in cytosolic expressions of COX2 as well as the reduction in nuclear localization of NFkB, and in peritoneal fluids, as shown by reduced levels of TNF-α, PGE2, and IL-1α. C8D has significant analgesic effects, as shown by reducing mast cell recruitment to the spinal cord and reducing the release of neurosensitizing and pro-inflammatory mediators.
In conclusion, the collected data showed that CBD has effective and coordinated effects in suppressing endometriosis.